Category: Health

Sciatic pain, causes and symptoms


The sciatic nerve is the biggest nerve in the body which starts from nerve roots of the spinal cord and it extends buttock area. This nerve ends down the lower limb of the body. Sciatica pain is very common but most of the time people know the symptoms but they do not recognize the problem with their medical names. The Sciatica pain is also one of them. This pain starts from the low back and with time it reaches to the back of the thigh. As the pain gets worse, it can reach to the below the knee. Many people feel stiffness in their buttocks and legs and they do not know the causes, sciatica pain can be one of them.

This problem can occur due to many reasons. Most people think that this problem occurs due to lumbar disc herniation when it presses on the nerve directly but if there is a small irritation on the sciatic nerve can also cause this pain. This irritation can be because of the abnormal intervertebral disc and this problem is known as radiculopathy in medical term. This problem can also occur due to adjacent bone, tumours, muscle, internal bleeding, infections in or around the lumbar spine, injury, and other causes. It can occur during pregnancy as well

What are causes of sciatica?

While sciatica is most commonly a result of a lumbar disc herniation directly pressing on the nerve, any cause of irritation or inflammation of the sciatic nerve can produce the symptoms of sciatica. This irritation of nerves as a result of an abnormal intervertebral disc is referred to as radiculopathy. Aside from a pinched nerve from a disc, other causes of sciatica include irritation of the nerve from adjacent bone, tumours, muscle, internal bleeding, infections in or around the lumbar spine, injury, and other causes. Sometimes sciatica can occur because of irritation of the sciatic nerve during pregnancy.

This problem causes a burning sensation and pain in the backbone, buttock, legs and other lower parts of the body. If the problem is very serious, it can cause numbness too. As the problem keeps increasing, it can lead to lumbar pain, hip pain, leg pain and buttock pain. Some people feel pain in their buttock when they sit for too long especially on a hard surface, it can because of the hardness of the surface and it can also be because of sciatica pain. Sometimes the pain goes away when the person changes the position but it will be temporary and the pain will come back eventually.

There are too many risks associated with this problem. It can lead to diseases like degenerative arthritis of the lumbar spine, lumbar disc disease, and slipped disc, and trauma or injury to the lumbar spine. So getting treatment for this problem is very important. There are treatments for this problem like sciatica physical therapy but it depends on the cause of the problem and its severity that which treatment will help. The time of the pain also depends on the severity of the pain. If the pain is too long and the person is not getting treatment, it can become a lifelong problem.

Getting Drug Packaging Right


Pharmaceutical companies play an important role in society. Not only do these organizations create the drugs that treat existing maladies, their scientists help plan for combatting future outbreaks. So they can focus on creating lifesaving treatments, many firms choose to outsource parenteral manufacturing services to a company that specializes in drug packaging.


When it comes to pharmaceuticals, most people tend to focus on the effectiveness of the product. They don’t, however, usually give much thought to how drugs get from the manufacturer to the patient. Nonetheless, preserving the quality and potency of pharmaceuticals is paramount in ensuring their effectiveness. Drug packaging, then, must adequately protect products until patients can use them. Parenteral manufacturing services have the expertise and technology to develop effective packaging.


Identification is an important component in drug packaging. Each container must describe its contents in a way that is easily understandable. It must also tell anyone who handles the product how to properly store the container to keep its contents wholesome. Likewise, the packaging also acts as marketing tool for the product. Finally, while the container must contain essential information, it should be easy to open.


Successfully storing and shipping pharmaceutical products usually requires three levels of packaging. First, products must remain in a primary container until administration. Primary packaging materials are often drug-specific. Then, the primary container must fit inside secondary packaging. The purpose of a second container is to group several doses of the product together. Finally, each product fits into tertiary packaging that serves as a protective vessel to help facilitate pharmaceutical shipment and delivery. Because each drug has its own storage requirements, manufacturers typically must develop specialized packaging for each product.


In modern society, packaging generally must meet environmental standards. When creating containers to store and ship pharmaceuticals, manufacturers often make recyclability a goal. As a result, pharmaceutical companies rely on the expertise of parenteral manufacturers to meet stringent environmental standards while successfully delivering products to patients.


To be certain packaging does its job, manufacturing firms must constantly evaluate containers and shipping methods. Much of the process requires the expertise of dedicated scientists. Since pharmaceutical companies often lack the technology and personnel to effectively assess packaging performance, collaborating with a third party is often necessary.

Parenteral manufacturing services help drug companies develop the packaging they need to get their products to market. By researching the appropriate means for protecting, distributing, storing, and using pharmaceutical products, a good parenteral manufacturing company is an invaluable partner in the pharmaceutical industry.